Manidipine

Drug Information: Manidipine

Manidipine is a dihydropyridine calcium channel blocker primarily used in the management of hypertension. It works by selectively blocking L-type calcium channels in vascular smooth muscle, leading to vasodilation and a reduction in blood pressure. Manidipine is distinguished by its long duration of action and high vascular selectivity, potentially reducing the risk of certain side effects associated with other calcium channel blockers.

Category

Antihypertensive

Mechanism of Action

Manidipine is a calcium channel blocker belonging to the dihydropyridine class. It exerts its antihypertensive effects by selectively blocking L-type calcium channels, primarily located in vascular smooth muscle cells. These channels are crucial for the influx of calcium ions, which trigger muscle contraction. By inhibiting calcium influx, manidipine reduces intracellular calcium concentrations, leading to vasodilation, particularly in the peripheral arterioles. This vasodilation decreases peripheral vascular resistance, resulting in a lowering of blood pressure. The drug’s high vascular selectivity is thought to contribute to its efficacy in managing hypertension with a potentially reduced risk of certain side effects associated with non-selective calcium channel blockers. Furthermore, some studies suggest Manidipine may also exhibit antioxidant and nephroprotective properties, although further research is needed to fully elucidate these potential benefits.

Clinical Uses

The primary clinical use of Manidipine is in the treatment of hypertension (high blood pressure). It is effective in lowering both systolic and diastolic blood pressure. Manidipine is often prescribed as a first-line agent or in combination with other antihypertensive medications, such as ACE inhibitors, angiotensin II receptor blockers (ARBs), or diuretics, to achieve optimal blood pressure control. Because of potential benefits, it may also be used in hypertensive patients with co-existing conditions such as renal dysfunction. The use of Manidipine should always be guided by a qualified healthcare professional.

Dosage

The typical adult dosage of Manidipine is 10-20 mg once daily, administered orally. The dosage may be adjusted based on individual patient response and blood pressure control. Pediatric dosage is not well established; therefore, Manidipine is generally not recommended for use in children. Always consult with a healthcare professional for appropriate dosage and administration instructions.

Indications

* Hypertension (high blood pressure)

Contraindications

Manidipine is generally contraindicated in the following conditions:

* Hypersensitivity to Manidipine or other dihydropyridine calcium channel blockers.
* Severe hypotension.
* Unstable angina.
* Acute myocardial infarction.
* Severe aortic stenosis.
* Pregnancy and breastfeeding.
* Severe hepatic impairment.

FAQ

**Q: What is Manidipine used for?**
A: Manidipine is primarily used to treat hypertension (high blood pressure).

**Q: How does Manidipine work?**
A: It works by blocking calcium channels in the smooth muscle of blood vessels, causing them to relax and widen, which lowers blood pressure.

**Q: What are the common side effects of Manidipine?**
A: Common side effects may include headache, flushing, dizziness, edema (swelling), and palpitations.

**Q: Can Manidipine be taken with other medications?**
A: Manidipine can interact with other medications. It’s crucial to inform your doctor about all the medications you are taking, including over-the-counter drugs and supplements.

**Q: How long does it take for Manidipine to start working?**
A: Manidipine typically starts to lower blood pressure within a few hours of taking the first dose, but it may take several weeks to achieve the full therapeutic effect.

**Q: What should I do if I miss a dose of Manidipine?**
A: If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

**Q: Is Manidipine safe for pregnant or breastfeeding women?**
A: Manidipine is generally contraindicated during pregnancy and breastfeeding due to potential risks to the fetus or infant.

**Q: Can I drink alcohol while taking Manidipine?**
A: Alcohol can increase the blood-pressure-lowering effect of Manidipine and may increase the risk of side effects like dizziness. It is best to avoid or limit alcohol consumption while taking this medication.